Neurology 2E

CASE 5:

Link the patient details:

https://nikhilasampathkumar.blogspot.com/2021/05/a-48-year-old-male-with-seizures-and.html?m=1

Questions: 

1) What could have been the reason for this patient to develop ataxia in the past 1 year?

Answer: By the history, Patient is an alcoholic and he has change in his gait since a year are the findings which leads to cause of ataxia.

Mechanism:Damage from alcohol is a common cause ofcerebellar ataxia. In patients with alcohol related ataxia, the symptoms affect gait (walking) and lower limbs more than arms and speech. It can also cause associated signs of peripheral neuropathy. Peripheral neuropathy is damage to the body's peripheral nervous system.

2) What was the reason for his IC bleed? Does Alcoholism contribute to bleeding diatheses?

Answer: Hemoglobin and its metabolites can exert deleterious effects on brain tissue through NO depletion and vasospasm, ROS production, stimulation of inflammatory response, inhibition of DNA repair, and glutamate release.

The impaired platelet function, together with the reduced platelet count, may contribute to the bleeding diathesis associated with chronic alcoholism and to the increased incidence and recurrence of gastrointestinal haemorrhage associated with excessive alcohol intake.